Changes in the Circulatory and Lymphatic Systems of Internal Genitals in Female Rats after Intravenous and Lymphotropic Administration of Multipotent Mesenchymal Stem Cells and Products Secreted by These Cells
- Authors: Dergacheva T.I.1, Shurlygina A.V.1, Starkova E.V.1, Poveshchenko O.V.1, Klimontov V.V.1, Konenkov V.I.1
-
Affiliations:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 168, No 1 (2019)
- Pages: 168-172
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/242334
- DOI: https://doi.org/10.1007/s10517-019-04669-9
- ID: 242334
Cite item
Abstract
We studied the effects of intravenous and lymphotropic administration of bone marrow multipotent mesenchymal stromal cells and products secreted by these cells into conditioned medium on the blood and lymph circulation in the uterus and ovaries, as well as on folliculogenesis in female Wistar rats. It was shown that stromal cells and conditioned media of these cells administered via both routes lead to an increase in the number and diameter of blood vessels in the uterine wall and in the cortical layer of the ovaries. Neither mesenchymal stromal cells, not conditioned media affected the ovarian follicular apparatus.
About the authors
T. I. Dergacheva
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
A. V. Shurlygina
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
E. V. Starkova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
O. V. Poveshchenko
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
V. V. Klimontov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: anna_v_s@mail.ru
Russian Federation, Novosibirsk