Comparison of Antitumor Effects of Combined and Separate Treatment with NO Synthase Inhibitor T1023 and PDK1 Inhibitor Dichloroacetate
- Authors: Filimonova M.V.1, Podosinnikova T.S.1, Samsonova A.S.1, Makarchuk V.M.1, Shevchenko L.I.1, Filimonov A.S.1
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Affiliations:
- A. F. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
- Issue: Vol 168, No 1 (2019)
- Pages: 92-94
- Section: Oncology
- URL: https://journals.rcsi.science/0007-4888/article/view/242249
- DOI: https://doi.org/10.1007/s10517-019-04655-1
- ID: 242249
Cite item
Abstract
Combined chronic treatment of Ehrlich solid carcinoma (EC) with an NOS inhibitor 1-isobutanoyl-2-isopropylisothiourea hydrobromide (T1023) and a PDK1 inhibitor dichloroacetate was accompanied by statistically significant synergetic antitumor effects manifested in a significant and stable suppression of neoplasm growth (by 55-65%). Separate treatment with T1023 and dichloroacetate induced moderate short-term inhibition of tumor growth (by 30-35%) followed by weakening of tumor sensitivity to these substances. These results attest to synergetic antitumor effects NOS inhibitor T1023 and PDK1 inhibitor dichloroacetate producing antiangiogenic and hypoxia-targeted cytotoxic effects, during their combined administration, which allows overcoming the adaptive potential of the tumors.
About the authors
M. V. Filimonova
A. F. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Email: tanchitto@mail.ru
Russian Federation, Obninsk
T. S. Podosinnikova
A. F. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: tanchitto@mail.ru
Russian Federation, Obninsk
A. S. Samsonova
A. F. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Email: tanchitto@mail.ru
Russian Federation, Obninsk
V. M. Makarchuk
A. F. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Email: tanchitto@mail.ru
Russian Federation, Obninsk
L. I. Shevchenko
A. F. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Email: tanchitto@mail.ru
Russian Federation, Obninsk
A. S. Filimonov
A. F. Tsyb Medical Radiological Research Center, Branch of the National Medical Research Center of Radiology, Ministry of Health of the Russian Federation
Email: tanchitto@mail.ru
Russian Federation, Obninsk