Comparative Preclinical Pharmacokinetics and Bioavailability of Antidepressant GSB-106 Tablet Form
- Authors: Kolyvanov G.B.1, Zherdev V.P.1, Gribakina O.G.1, Bochkov P.O.1, Shevchenko R.V.1, Litvin A.A.1, Blynskaya E.V.2, Bueva V.V.2
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Affiliations:
- Laboratory of Pharmacokinetics
- Laboratory of Finished Dosage Forms, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
- Issue: Vol 167, No 5 (2019)
- Pages: 637-640
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241978
- DOI: https://doi.org/10.1007/s10517-019-04587-w
- ID: 241978
Cite item
Abstract
Pharmacokinetics and relative bioavailability of antidepressant GSB-106 (hexamethylendiamide bis-(N-monosuccinyl-L-seryl-L-lysine) were determined in rabbits after single oral administration of the pharmaceutical substance and tablet mass. GSB-106 concentrations in the blood plasma were determined by HPLC-mass spectrometry. Relative bioavailability of GSB-106 tablet form was 160.79±24.33%.
About the authors
G. B. Kolyvanov
Laboratory of Pharmacokinetics
Author for correspondence.
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
V. P. Zherdev
Laboratory of Pharmacokinetics
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
O. G. Gribakina
Laboratory of Pharmacokinetics
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
P. O. Bochkov
Laboratory of Pharmacokinetics
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
R. V. Shevchenko
Laboratory of Pharmacokinetics
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
A. A. Litvin
Laboratory of Pharmacokinetics
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
E. V. Blynskaya
Laboratory of Finished Dosage Forms, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Russian Federation, Moscow
V. V. Bueva
Laboratory of Finished Dosage Forms, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: litbiopharm@yandex.ru
Russian Federation, Moscow