Distribution of Polymorphisms of the Renin—Angiotensin System Genes (ACE, AGT, and AGTR1), ITGB3, and FTO in Pregnant Patients with Hypertensive Disorders
- Authors: Zotova T.Y.1, Lapaev N.N.1, Azova M.M.2, Blagonravov M.L.1, Gigani O.O.2, Ait Aissa A.2, Denisova A.P.1
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Affiliations:
- V. A. Frolov Department of General Pathology and Pathophysiology
- Department of Biology and General Genetics, Medical Institute, Peoples’ Friendship University of Russia
- Issue: Vol 167, No 1 (2019)
- Pages: 74-78
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/241467
- DOI: https://doi.org/10.1007/s10517-019-04464-6
- ID: 241467
Cite item
Abstract
The study included pregnant women aged 23-41 years with preeclampsia and gestation-associated arterial hypertension at weeks 27-40 and patients with essential arterial hypertension developing under conditions of the metabolic syndrome and without it. Frequency analysis of polymorphisms of the renin—angiotensin system genes (ACE, AGT, and AGTR1), ITGB3, FTO and their associations confirmed the syndrome nature of hypertensive disorders in pregnancy. The presence allele T of AGT gene and/or allele C of AGTR1 gene in the genotype of patients with preeclampsia was associated with higher BP and pressure load over 24 h. Allele D of ACE gene was also essential for BP parameters (pressure load) in patients with preeclampsia and gestation-associated arterial hypertension. Due to high genetic heterogeneity of the preeclampsia syndrome and genetic differences in the incidence of the studied gene polymorphisms in preeclampsia and gestation-associated arterial hypertension, no direct associations between these gestation disorders and polymorphic markers of the renin—angiotensin system genes can be established. However, polymorphisms of the renin—angiotensin system genes are essential for the 24-h dynamics of BP and pressure load under conditions of hypertensive disorders in pregnancy.
About the authors
T. Yu. Zotova
V. A. Frolov Department of General Pathology and Pathophysiology
Author for correspondence.
Email: zotovat@mail.ru
Russian Federation, Moscow
N. N. Lapaev
V. A. Frolov Department of General Pathology and Pathophysiology
Email: zotovat@mail.ru
Russian Federation, Moscow
M. M. Azova
Department of Biology and General Genetics, Medical Institute, Peoples’ Friendship University of Russia
Email: zotovat@mail.ru
Russian Federation, Moscow
M. L. Blagonravov
V. A. Frolov Department of General Pathology and Pathophysiology
Email: zotovat@mail.ru
Russian Federation, Moscow
O. O. Gigani
Department of Biology and General Genetics, Medical Institute, Peoples’ Friendship University of Russia
Email: zotovat@mail.ru
Russian Federation, Moscow
A. Ait Aissa
Department of Biology and General Genetics, Medical Institute, Peoples’ Friendship University of Russia
Email: zotovat@mail.ru
Russian Federation, Moscow
A. P. Denisova
V. A. Frolov Department of General Pathology and Pathophysiology
Email: zotovat@mail.ru
Russian Federation, Moscow