Immunohistochemical Assessment of the Compensatory Responses in Rat Olfactory Bulbs after 6-Hydroxydopamine-Induced Lesion of the Substantia Nigra
- Authors: Voronkov D.N.1, Khudoerkov R.M.1, Sal’nikova O.V.1, Stavrovskaya A.V.1, Ol’shanskii A.S.1, Gushchina A.S.1
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Affiliations:
- Research Center of Neurology
- Issue: Vol 166, No 6 (2019)
- Pages: 811-815
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241395
- DOI: https://doi.org/10.1007/s10517-019-04446-8
- ID: 241395
Cite item
Abstract
We assessed changes of olfactory bulbs in rata with 6-hydroxydopamine destruction of the substantia nigra. The expression of marker proteins of immature and differentiated neurons and glia (vimentin, PSA-NCAM, tyrosine hydroxylase, and S100) was analyzed by immunohistochemical and morphometric methods. The number of periglomerular dopamine neurons and astroglia in the olfactory bulbs increased on the side of toxin injection and expression of PSA-NCAM and vimentin increased in the rostral migratory stream. Destruction of the substantia nigra shifted differentiation of neuronal progenitors towards the dopaminergic phenotype and increased their survival in the olfactory bulbs, which can be explained by increased expression of PSA-NCAM.
About the authors
D. N. Voronkov
Research Center of Neurology
Author for correspondence.
Email: voronkovdm@gmail.com
Russian Federation, Moscow
R. M. Khudoerkov
Research Center of Neurology
Email: voronkovdm@gmail.com
Russian Federation, Moscow
O. V. Sal’nikova
Research Center of Neurology
Email: voronkovdm@gmail.com
Russian Federation, Moscow
A. V. Stavrovskaya
Research Center of Neurology
Email: voronkovdm@gmail.com
Russian Federation, Moscow
A. S. Ol’shanskii
Research Center of Neurology
Email: voronkovdm@gmail.com
Russian Federation, Moscow
A. S. Gushchina
Research Center of Neurology
Email: voronkovdm@gmail.com
Russian Federation, Moscow