Expression of Aβ42, τ-Protein, p16, p53 in Buccal Epithelium: Prospects for Use in the Diagnostics of Alzheimer’s Disease and Rate of Aging
- Authors: Zuev V.A.1, Dyatlova A.S.1,2, Lin’kova N.S.1,2, Kvetnaya T.V.1
-
Affiliations:
- St. Petersburg Research Center Institute of Bioregulation and Gerontology
- Peter the Great St. Petersburg Polytechnic University
- Issue: Vol 166, No 5 (2019)
- Pages: 676-679
- Section: Biogerontology
- URL: https://journals.rcsi.science/0007-4888/article/view/241274
- DOI: https://doi.org/10.1007/s10517-019-04416-0
- ID: 241274
Cite item
Abstract
The expression of Aβ42, and τ-protein, and p16 and p53 proteins was analyzed in the buccal epithelium of elderly and senile patients with Alzheimer’s disease. We revealed enhanced synthesis of Alzheimer’s disease markers Aβ42 (by 15-30 times) and τ-protein (by 5 times) in comparison with the corresponding values in people without neurodegenerative pathology of the same age groups. In addition, increased synthesis of proteins of cell aging and apoptosis p16 (by 6-10 times) and p53 (by 2-3 times) was observed in patients in comparison with age-matched persons without neuropathology. These data suggest that complex analysis of the expression of Aβ42, τ-protein, p16, and p53 in the buccal epithelium is a promising method for in vivo diagnosis of Alzheimer’s disease and assessment of the rate of aging during the development of this pathology.
About the authors
V. A. Zuev
St. Petersburg Research Center Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
A. S. Dyatlova
St. Petersburg Research Center Institute of Bioregulation and Gerontology; Peter the Great St. Petersburg Polytechnic University
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg
N. S. Lin’kova
St. Petersburg Research Center Institute of Bioregulation and Gerontology; Peter the Great St. Petersburg Polytechnic University
Author for correspondence.
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg
T. V. Kvetnaya
St. Petersburg Research Center Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg