Death Mechanisms of Pulmonary Alveolocytes in Mice Infected with Influenza Viruses A/H1N1/California/04/2009 and A/H5N1/Goose/Krasnoozerskoye/627/05
- Authors: Sharkova T.V.1, Shkurupy V.A.2,3, Shestopalov A.M.2, Potapova O.V.1, Cherdantseva L.A.2, Kovner A.V.2
-
Affiliations:
- Optimum Medical Laboratory, Research-and-Educational Center
- Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine
- Novosibirsk State Medical University
- Issue: Vol 166, No 5 (2019)
- Pages: 637-640
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241245
- DOI: https://doi.org/10.1007/s10517-019-04408-0
- ID: 241245
Cite item
Abstract
In CBA mice infected with influenza viruses A/H1N1/California/04/2009 and A/H5N1/Goose/Krasnoozerskoye/627/05 in a dose of 10 MLD50, the mechanisms of death of pulmonary alveolocytes over 10 postinfection days were studied by light microscopy, immunohistochemistry, and morphometry. In mice infected with A/H1N1, alveolocytes died predominantly via necrosis, while apoptosis mostly employed the mitochondrial pathway. In mice infected with A/H5N1, apoptosis was the dominant mechanism of alveolocyte death proceeded via membrane receptor signaling followed by switching to FAS-mediated pathway via activation of FADD, the apoptotic signal transduction protein.
About the authors
T. V. Sharkova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Russian Federation, Sochi
V. A. Shkurupy
Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine; Novosibirsk State Medical University
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk; Novosibirsk
A. M. Shestopalov
Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
O. V. Potapova
Optimum Medical Laboratory, Research-and-Educational Center
Email: cherdanceff@yandex.ru
Russian Federation, Sochi
L. A. Cherdantseva
Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine
Author for correspondence.
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk
A. V. Kovner
Research Institute of Experimental and Clinical Medicine, Federal Research Center of Fundamental and Translational Medicine
Email: cherdanceff@yandex.ru
Russian Federation, Novosibirsk