Pelvic Electric Potential as a Marker of Autonomic Dysfunctions and Risk Factor of Neurogenic Arrhythmias in Humans
- Authors: Kabanova I.V.1, Makarov A.D.2, Revenko S.V.3, Nikitin S.S.4, Kirpatovskii V.I.1, Moiseev S.V.5, Gavrilov I.Y.2
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Affiliations:
- N. A. Lopatkin Research Institute of Urology and Interventional Radiology — Affiliated Branch of National Research Center of Radiology, Ministry of Health of the Russian Federation
- Department of Bioengineering Technologies and Support of Research
- Department of Physiology, Research Institute of Cardiology, National Medical Research Cardiology Center, Ministry of Health of the Russian Federation
- Medical Center “Practical Neurology”
- E. M. Tareev Clinic of Nephrology, Internal and Occupational Diseases, Ministry of Health of the Russian Federation
- Issue: Vol 166, No 3 (2019)
- Pages: 404-408
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241049
- DOI: https://doi.org/10.1007/s10517-019-04360-z
- ID: 241049
Cite item
Abstract
Differential high-resolution ECG (V1-V2) and pelvic electric potential measured between the coccyx and perineum were recorded simultaneously in resting supine position in men with autonomic nervous system disorders (N=37). In healthy volunteers (N=23), the effective (rms) value of PEP presented by median and interdecile range was 30 (20-80) μV within the frequency band of 0.03-80 Hz. In patients, the corresponding value was significantly higher: 140 (80-280) μV. In both groups, the amplitude harmonic spectrum of pelvic electric potential decreased monotonically with frequency according to 1/f1.6 law. In some patients (N=16), rare single or grouped high-amplitude impulses (up to 1 mV) of pelvic electric potential with total duration of about 1 sec were observed; of them, some persons (N=7) demonstrated practically one-to-one synchronous relations between these impulses and arrhythmia episodes indicating abnormal activity of the autonomic nervous system as their most probable common cause. The high-amplitude pelvic electric potential impulses were also observed in ECG records as interference signals with an amplitude attaining 50 μV. Thus, high-resolution ECG and pelvic electric potential can reveal the risk of abnormal neurogenic influences on the heart. The data obtained are discussed in relation to diagnostics of the autonomic nervous system disorders, neurogenic arrhythmias, and risk of sudden cardiac death.
About the authors
I. V. Kabanova
N. A. Lopatkin Research Institute of Urology and Interventional Radiology — Affiliated Branch of National Research Center of Radiology, Ministry of Health of the Russian Federation
Email: s_revenko@mail.ru
Russian Federation, Moscow
A. D. Makarov
Department of Bioengineering Technologies and Support of Research
Email: s_revenko@mail.ru
Russian Federation, Moscow
S. V. Revenko
Department of Physiology, Research Institute of Cardiology, National Medical Research Cardiology Center, Ministry of Health of the Russian Federation
Author for correspondence.
Email: s_revenko@mail.ru
Russian Federation, Moscow
S. S. Nikitin
Medical Center “Practical Neurology”
Email: s_revenko@mail.ru
Russian Federation, Moscow
V. I. Kirpatovskii
N. A. Lopatkin Research Institute of Urology and Interventional Radiology — Affiliated Branch of National Research Center of Radiology, Ministry of Health of the Russian Federation
Email: s_revenko@mail.ru
Russian Federation, Moscow
S. V. Moiseev
E. M. Tareev Clinic of Nephrology, Internal and Occupational Diseases, Ministry of Health of the Russian Federation
Email: s_revenko@mail.ru
Russian Federation, Moscow
I. Yu. Gavrilov
Department of Bioengineering Technologies and Support of Research
Email: s_revenko@mail.ru
Russian Federation, Moscow