Soluble Ligand of the Immune Checkpoint Receptor (sPD-L1) in Blood Serum of Patients with Renal Cell Carcinoma
- Authors: Kushlinskii N.E.1, Gershtein E.S.1, Morozov A.A.2, Goryacheva I.O.1, Filipenko M.L.3, Alferov A.A.1, Bezhanova S.D.1, Bazaev V.V.2, Kazantseva I.A.2
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Affiliations:
- N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
- M. F. Vladimirsky Moscow Regional Research Clinical Institute
- Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
- Issue: Vol 166, No 3 (2019)
- Pages: 353-357
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/241009
- DOI: https://doi.org/10.1007/s10517-019-04349-8
- ID: 241009
Cite item
Abstract
The content of the soluble ligand of the immune checkpoint receptor (sPD-L1) was determined in the blood serum of 106 patients with renal cell carcinoma and 11 patients with benign kidney tumors by direct ELISA (Human sPD-L1 Platinum ELISA; Affimetrix, eBioscience). The control group included 19 healthy men and 18 women. Serum level of sPD-L1 significantly surpassed the control values in both patients with primary renal cancer (p<0.0001) and in patients examined during disease progression (p<0.05). In patients with benign kidney tumors, the level of this marker was significantly higher than in the control (p<0.05), but lower than in patients with renal cell carcinoma. The sPD-L1 level significantly increased with disease stage (p<0.001); it was higher in the presence of metastases in regional lymph nodes irrespective of their number (N1 or N2) than in the absence of metastases (N0); it was also increased in patients with distant metastases (M1) and patients with grade III-IV tumors in comparison with grade III-IV tumors (p<0.05). The highest sPD-L1 levels were recorded in patients with tumor size corresponding to T2 and T3 and decreased in patients with T4 tumors. Thus, sPD-L1 level in patients with renal cell carcinoma correlated with tumor grade and metastasizing and can be considered as a promising marker in monitoring of the effect of anti-PD1/PD-L1 therapy.
About the authors
N. E. Kushlinskii
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: biochimia@yandex.ru
Russian Federation, Moscow
E. S. Gershtein
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Russian Federation, Moscow
A. A. Morozov
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Email: biochimia@yandex.ru
Russian Federation, Moscow
I. O. Goryacheva
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Russian Federation, Moscow
M. L. Filipenko
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences
Email: biochimia@yandex.ru
Russian Federation, Novosibirsk
A. A. Alferov
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Russian Federation, Moscow
S. D. Bezhanova
N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation
Email: biochimia@yandex.ru
Russian Federation, Moscow
V. V. Bazaev
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Email: biochimia@yandex.ru
Russian Federation, Moscow
I. A. Kazantseva
M. F. Vladimirsky Moscow Regional Research Clinical Institute
Email: biochimia@yandex.ru
Russian Federation, Moscow
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