Effect of TRPV1 on Activity of Isoforms of Constitutive Nitric Oxide Synthase during Regulation of Bicarbonate Secretion in the Stomach
- Authors: Zolotarev V.A.1, Andreeva Y.V.1, Khropycheva R.P.1
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Affiliations:
- I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 166, No 3 (2019)
- Pages: 310-312
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240989
- DOI: https://doi.org/10.1007/s10517-019-04339-w
- ID: 240989
Cite item
Abstract
Application of mild irritants (1 M NaCl; pH 2.0) on the gastric mucosa potentiates the protective secretion of bicarbonates by epithelial cells. This response is mainly mediated by capsaicin-sensitive afferent nerve endings located in the submucosa. It was shown that activation of vanilloid type 1 receptors (TRPV1) induced by exogenous acidification of GM is not sufficient to potentiate the production of HCO3, including production depending on neuronal NO synthase. However, the effect of exogenous acid on TRPV1 leads to activation of endothelial NO synthase that restrict the gastric secretion of \( {\mathrm{HCO}}_3^{-} \).
About the authors
V. A. Zolotarev
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Author for correspondence.
Email: vasiliy_zolotarev@hotmail.com
Russian Federation, St. Petersburg
Yu. V. Andreeva
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: vasiliy_zolotarev@hotmail.com
Russian Federation, St. Petersburg
R. P. Khropycheva
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: vasiliy_zolotarev@hotmail.com
Russian Federation, St. Petersburg