In Vitro  Study of the Modulatory Effects of Levofloxacin and BCG on Secretion of Proinflammatory Cytokines in Infiltrative Pulmonary Tuberculosis

V. A. Serebryakova; O. I. Urazova; V. V. Novitsky; A. I. Vengerovskii; T. E. Kononova

doi:10.1007/s10517-018-4319-z

In Vitro Study of the Modulatory Effects of Levofloxacin and BCG on Secretion of Proinflammatory Cytokines in Infiltrative Pulmonary Tuberculosis

Authors: Serebryakova V.A.¹, Urazova O.I.¹, Novitsky V.V.¹, Vengerovskii A.I.¹, Kononova T.E.¹
Affiliations:
1. Siberian State Medical University, Ministry of Health of the Russian Federation
Issue: Vol 166, No 2 (2018)
Pages: 225-228
Section: Article
URL: https://journals.rcsi.science/0007-4888/article/view/240920
DOI: https://doi.org/10.1007/s10517-018-4319-z
ID: 240920

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Abstract

The effects levofloxacin (fluoroquinolone) and vaccinal BCG strain on cytokine production by blood mononuclear leukocytes was studied in patients with infiltrative pulmonary tuberculosis. Combined treatment with levofloxacin and vaccinal BCG strain suppressed the production of TNFα in drug-resistant pulmonary tuberculosis and production of IL-12 and IFNγ in drug-sensitive tuberculosis.