Neuroprotective Lithium Salts Protect Pancreatic β-Сells from Damage
- Authors: Ostrovskaya R.U.1, Ivanov S.V.1, Durnev A.D.1
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Affiliations:
- Laboratory of Psychopharmacology, V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 165, No 6 (2018)
- Pages: 758-762
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240728
- DOI: https://doi.org/10.1007/s10517-018-4259-7
- ID: 240728
Cite item
Abstract
We studied antidiabetic effects and cytoprotective activity of two lithium salts (lithium chloride and lithium carbonate) on the model of streptozotocin-induced diabetes mellitus type 2 in Wistar rats. Using the method of β-cells detection with antibodies to insulin, we demonstrated that streptozotocin reduced the number of β-cells and impaired their morphological structure. Both lithium preparations administered to diabetic animals for 28 days in doses of 10 and 8.9 mg/kg, respectively, attenuated the damaging effect of streptozotocin. This cytoprotective effect of lithium salts manifested in weakening of hyperglycemia, polyphagia, polydipsia, and weight loss. A satisfactory correlation between the morphometric data and blood glucose levels was revealed. The mechanisms of the multitarget action of lithium salts are discussed.
About the authors
R. U. Ostrovskaya
Laboratory of Psychopharmacology, V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow
S. V. Ivanov
Laboratory of Psychopharmacology, V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow
A. D. Durnev
Laboratory of Psychopharmacology, V. V. Zakusov Research Institute of Pharmacology
Email: rita.ostrovskaya@gmail.com
Russian Federation, Moscow