Oxidative Status in Different Areas of the Cerebral Cortex of Wistar Rats during Focal Ischemia and Its Modulation with Carnosine
- Authors: Fedorova T.N.1, Devyatov A.A.1,2, Berezhnoi D.S.1,3, Stvolinskii S.L.1, Morozova M.P.3, Gavrilova S.A.2, Tutelyan V.A.2
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Affiliations:
- Research Center of Neurology
- Federal Research Center of Nutrition and Biotechnology
- M. V. Lomonosov Moscow State University
- Issue: Vol 165, No 6 (2018)
- Pages: 746-750
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/240720
- DOI: https://doi.org/10.1007/s10517-018-4256-x
- ID: 240720
Cite item
Abstract
Oxidative status was assessed in different areas of the cerebral cortex of male Wistar rats under normal condition and during permanent 24-h focal ischemia. In intact animals, the level of lipid hydroperoxides in the frontal lobes of both hemispheres was by 36% higher than in other cortical areas, while total antioxidant activity was by 25% higher than in other areas. During ischemia, changes in oxidative status were localized only in the ischemic focus and penumbra zone and did not involve other cortical areas. We demonstrated for the first time a neuroprotective effect of therapeutic administration of carnosine in low doses (50 mg/kg) on parameters of the oxidative status under conditions of focal ischemia comparable to its effect of high doses (500 mg/kg) as well as its local effect in the penumbra zone. A dose-dependent effect of carnosine on antioxidant activity in the penumbra zone during ischemia was also demonstrated. These findings confirm effectiveness of not only preventive carnosine administration, but also its application in the postischemic period of the stroke.
About the authors
T. N. Fedorova
Research Center of Neurology
Author for correspondence.
Email: tnf51@bk.ru
Russian Federation, Moscow
A. A. Devyatov
Research Center of Neurology; Federal Research Center of Nutrition and Biotechnology
Email: tnf51@bk.ru
Russian Federation, Moscow; Moscow
D. S. Berezhnoi
Research Center of Neurology; M. V. Lomonosov Moscow State University
Email: tnf51@bk.ru
Russian Federation, Moscow; Moscow
S. L. Stvolinskii
Research Center of Neurology
Email: tnf51@bk.ru
Russian Federation, Moscow
M. P. Morozova
M. V. Lomonosov Moscow State University
Email: tnf51@bk.ru
Russian Federation, Moscow
S. A. Gavrilova
Federal Research Center of Nutrition and Biotechnology
Email: tnf51@bk.ru
Russian Federation, Moscow
V. A. Tutelyan
Federal Research Center of Nutrition and Biotechnology
Email: tnf51@bk.ru
Russian Federation, Moscow