Effect of Thymalin on the Tumor and Thymus under Conditions of Activation Therapy In Vivo
- Authors: Zhukova G.V.1, Schikhlyarova A.I.1, Barteneva T.A.1, Shevchenko A.N.1, Zakharyuta F.M.1
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Affiliations:
- Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
- Issue: Vol 165, No 1 (2018)
- Pages: 80-83
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239995
- DOI: https://doi.org/10.1007/s10517-018-4104-z
- ID: 239995
Cite item
Abstract
Pronounced antitumor effect of Thymalin in doses lower than the therapeutic doses was shown in experiments on albino outbred male rats with transplanted sarcoma 45. Tumor growth arrest and its regression were observed in more than half of animals and in other cases, the growth was suppressed by 78%. Microstructural changes in the thymus were analyzed. Significant increase in lymphoproliferative activity and the content of tissue basophils and plasmocytes in the thymus lobules was observed. Tumor regression was accompanied by the development of stable antistress adaptation reactions of calm and elevated activation. High efficiency of Thymalin can be attributed to the use of lower doses of the substance and their modulation during the treatment course in accordance with the regimes of activation therapy.
About the authors
G. V. Zhukova
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: galya_57@mail.ru
Russian Federation, Rostov-on-Don
A. I. Schikhlyarova
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: galya_57@mail.ru
Russian Federation, Rostov-on-Don
T. A. Barteneva
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: galya_57@mail.ru
Russian Federation, Rostov-on-Don
A. N. Shevchenko
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: galya_57@mail.ru
Russian Federation, Rostov-on-Don
F. M. Zakharyuta
Rostov Research Institute of Oncology, Ministry of Health of the Russian Federation
Email: galya_57@mail.ru
Russian Federation, Rostov-on-Don