In Vivo Experimental Study of Biological Compatibility of Tissue Engineered Tracheal Construct in Laboratory Primates
- Authors: Gilevich I.V.1, Sotnichenko A.S.2, Karal-ogly D.D.3, Gubareva E.A.2, Kuevda E.V.2, Polyakov I.S.1, Lapin B.A.3, Orlov S.V.3, Porkhanov V.A.1, Chekhonin V.P.4
-
Affiliations:
- Research Institute — S. V. Ochapovsky Regional Clinic Hospital No. 1
- Kuban State Medical University, the Ministry of Health of Russia
- Research Institute of Medical Primatology
- N. I. Pirogov National Research Medical University, the Ministry of Health of Russia
- Issue: Vol 164, No 6 (2018)
- Pages: 770-774
- Section: Primatology
- URL: https://journals.rcsi.science/0007-4888/article/view/239905
- DOI: https://doi.org/10.1007/s10517-018-4077-y
- ID: 239905
Cite item
Abstract
Biological compatibility of a tissue engineered construct of the trachea (synthetic scaffold) and allogenic mesenchymal stem cells was studied on laboratory Papio hamadryas primates. Subcutaneous implantation and orthotopic transplantations of tissue engineered constructs were carried out. Histological studies of the construct showed chaotically located filaments and mononuclear cells fixed to them. Development of a fine connective tissue capsule was found at the site of subcutaneous implantation of the tissue engineered construct. The intact structure of the scaffold populated by various cell types in orthotopic specimens was confirmed by expression of specific proteins. The results indicated biological compatibility of the tissue engineered construct with the mesenchymal stem cells; no tissue rejection reactions were recorded; simulation of respiratory disease therapy on Papio hamadryas proved to be an adequate model.
About the authors
I. V. Gilevich
Research Institute — S. V. Ochapovsky Regional Clinic Hospital No. 1
Author for correspondence.
Email: gilev@list.ru
Russian Federation, Krasnodar
A. S. Sotnichenko
Kuban State Medical University, the Ministry of Health of Russia
Email: gilev@list.ru
Russian Federation, Krasnodar
D. D. Karal-ogly
Research Institute of Medical Primatology
Email: gilev@list.ru
Russian Federation, Sochi
E. A. Gubareva
Kuban State Medical University, the Ministry of Health of Russia
Email: gilev@list.ru
Russian Federation, Krasnodar
E. V. Kuevda
Kuban State Medical University, the Ministry of Health of Russia
Email: gilev@list.ru
Russian Federation, Krasnodar
I. S. Polyakov
Research Institute — S. V. Ochapovsky Regional Clinic Hospital No. 1
Email: gilev@list.ru
Russian Federation, Krasnodar
B. A. Lapin
Research Institute of Medical Primatology
Email: gilev@list.ru
Russian Federation, Sochi
S. V. Orlov
Research Institute of Medical Primatology
Email: gilev@list.ru
Russian Federation, Sochi
V. A. Porkhanov
Research Institute — S. V. Ochapovsky Regional Clinic Hospital No. 1
Email: gilev@list.ru
Russian Federation, Krasnodar
V. P. Chekhonin
N. I. Pirogov National Research Medical University, the Ministry of Health of Russia
Email: gilev@list.ru
Russian Federation, Moscow