Expression of microRNA Genes MIR221, MIR222, and MIR181B1 Increases during Induction of Inflammation in the Endothelial Barrier Model
- Authors: Knyazev E.N.1, Mal’tseva D.V.1, Zakharyants A.A.1, Zakharova G.S.1, Zhidkova O.V.2, Poloznikov A.A.1
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Affiliations:
- BioClinicum Research Center
- State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
- Issue: Vol 164, No 6 (2018)
- Pages: 749-752
- Section: Genetics
- URL: https://journals.rcsi.science/0007-4888/article/view/239893
- DOI: https://doi.org/10.1007/s10517-018-4072-3
- ID: 239893
Cite item
Abstract
We studied expression profile of microRNA and their target genes in human umbilical vein endothelial cells (HUVEC) during proinflammatory activation with TNFα. TNFα-induced activation of HUVEC was accompanied by a decrease in the expression of CDKN1B, HIST1H3D, and OIP5 genes that are the common target genes for mature microRNA encoded by MIR221, MIR222, and MIR181B1 genes, whose expression increases in activated cells. Proteins encoded by HIST1H3D and OIP5 genes are associated with chromatin compaction and cell cycle. Our results suggest that fetal endothelial microRNA can appear in the maternal blood during various pathological states, e.g., under conditions of preeclampsia.
About the authors
E. N. Knyazev
BioClinicum Research Center
Author for correspondence.
Email: e.knyazev@bioclinicum.com
Russian Federation, Moscow
D. V. Mal’tseva
BioClinicum Research Center
Email: e.knyazev@bioclinicum.com
Russian Federation, Moscow
A. A. Zakharyants
BioClinicum Research Center
Email: e.knyazev@bioclinicum.com
Russian Federation, Moscow
G. S. Zakharova
BioClinicum Research Center
Email: e.knyazev@bioclinicum.com
Russian Federation, Moscow
O. V. Zhidkova
State Research Center Institute of Biomedical Problems, Russian Academy of Sciences
Email: e.knyazev@bioclinicum.com
Russian Federation, Moscow
A. A. Poloznikov
BioClinicum Research Center
Email: e.knyazev@bioclinicum.com
Russian Federation, Moscow