Endogenous Regulators of the Immune System (sCD100, Malonic Dialdehyde, and Arginase)
- Authors: Kazimirskii A.N.1, Poryadin G.V.1, Salmasi Z.M.1, Semenova L.Y.1
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Affiliations:
- Department of Pathology and Clinical Pathology, N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
- Issue: Vol 164, No 5 (2018)
- Pages: 693-700
- Section: Review
- URL: https://journals.rcsi.science/0007-4888/article/view/239865
- DOI: https://doi.org/10.1007/s10517-018-4061-6
- ID: 239865
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Abstract
Tissue damage in various diseases, hypoxic conditions, and some pathologies are associated with production of endogenous factors such as the soluble form of the surface receptor CD100, malonic dialdehyde, and arginase and their release into circulation. These factors modulate functional state of lymphocytes in the immune system: potentiate activation of B lymphocytes, activate synthesis and secretion of IL-25 and IL-17 cytokines, and suppress proliferative activity of T lymphocytes, thus modulating immunological reactivity of the organism. Reactions of innate and adaptive immunity develop against the background of changed immunological reactivity, which should be taken into account in the development of pathogenetically substantiated therapy.
About the authors
A. N. Kazimirskii
Department of Pathology and Clinical Pathology, N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Author for correspondence.
Email: alnica10@mail.ru
Russian Federation, Moscow
G. V. Poryadin
Department of Pathology and Clinical Pathology, N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Email: alnica10@mail.ru
Russian Federation, Moscow
Zh. M. Salmasi
Department of Pathology and Clinical Pathology, N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Email: alnica10@mail.ru
Russian Federation, Moscow
L. Yu. Semenova
Department of Pathology and Clinical Pathology, N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia
Email: alnica10@mail.ru
Russian Federation, Moscow