α-Tocopherol Reduces Morphological Changes and Oxidative Stress during Gentamicin-Induced Acute Renal Failure
- Authors: Stojiljkovic N.1, Ilic S.1, Veljkovic M.1, Todorovic J.2, Mladenovic M.2
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Affiliations:
- Institute of Physiology
- Faculty of Medicine, University of Nis
- Issue: Vol 164, No 4 (2018)
- Pages: 442-445
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239674
- DOI: https://doi.org/10.1007/s10517-018-4008-y
- ID: 239674
Cite item
Abstract
We studied the effect of α-tocopherol on gentamicin-induced morphological and functional changes in the kidneys of Wistar rats. Special attention was paid to the ability of α-tocopherol administered in combination with gentamicin to correct ultrastructural changes in the glomerular basal membrane and tubules. Combined treatment with α-tocopherol (100 mg/kg) and gentamicin (100 mg/kg) led to correction of histopathological and biochemical changes and oxidative injury to the kidneys induced by this antibiotic.
About the authors
N. Stojiljkovic
Institute of Physiology
Author for correspondence.
Email: nenstojiljkovic@gmail.com
Serbia, Nis
S. Ilic
Institute of Physiology
Email: nenstojiljkovic@gmail.com
Serbia, Nis
M. Veljkovic
Institute of Physiology
Email: nenstojiljkovic@gmail.com
Serbia, Nis
J. Todorovic
Faculty of Medicine, University of Nis
Email: nenstojiljkovic@gmail.com
Serbia, Nis
M. Mladenovic
Faculty of Medicine, University of Nis
Email: nenstojiljkovic@gmail.com
Serbia, Nis