Sex Differences in the Production of SLC5A5, Thyroid Peroxidase, and Thyroid Hormones in Pubertal Rats Exposed to Endocrine Disruptor Dichlorodiphenyltrichloroethane (DDT) during Postnatal Ontogeny
- Authors: Yaglova N.V.1, Sledneva Y.P.1, Nazimova S.V.1, Obernikhin S.S.1, Yaglov V.V.1
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Affiliations:
- Research Institute of Human Morphology
- Issue: Vol 164, No 4 (2018)
- Pages: 430-433
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239666
- DOI: https://doi.org/10.1007/s10517-018-4005-1
- ID: 239666
Cite item
Abstract
Sex differences in the expression of iodide transporter SLC5A5 and thyroid peroxidase in thyroid follicular epithelium and thyroid serum profile were assessed in pubertal rats exposed to endocrine disruptor DDT starting from the first postnatal day. It was found that exposure to DDT reduced expression of SLC5A5 in peripheral regions of thyroid lobes in males and in central regions in females. The most pronounced sex differences were observed in thyroid peroxidase expression that remained sensitive to thyroid stimulating hormone regulation in males and lost sensitivity to pituitary stimulation in females after exposure to disruptor, which determines more pronounced hypothyroidism in females.
About the authors
N. V. Yaglova
Research Institute of Human Morphology
Author for correspondence.
Email: yaglova@mail.ru
Russian Federation, Moscow
Yu. P. Sledneva
Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
S. V. Nazimova
Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
S. S. Obernikhin
Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
V. V. Yaglov
Research Institute of Human Morphology
Email: yaglova@mail.ru
Russian Federation, Moscow
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