Balance of Fatty Acids and Their Correlations with Parameters of Lipid Metabolism and Markers of Inflammation in Men with Coronary Atherosclerosis
- Authors: Polonskaya Y.V.1, Shramko V.S.1, Morozov S.V.2, Chernyak E.I.2, Chernyavsky A.M.3, Ragino Y.I.1
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Affiliations:
- Research Institute of Therapy and Preventive Medicine
- N. N. Vorozhtsov Novosibirsk State University of Organic Chemistry
- E.N. Meshalkin Siberian Federal Biomedical Research Center, Ministry of Health of the Russian Federation
- Issue: Vol 164, No 1 (2017)
- Pages: 33-35
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239341
- DOI: https://doi.org/10.1007/s10517-017-3920-x
- ID: 239341
Cite item
Abstract
We studied the balance of fatty acids and their correlation with parameters of lipid metabolism and inflammation markers in men with coronary atherosclerosis. In the blood of patients and healthy men, the content of myristic (C14:0), pentadecanoic (C15:0), palmitic (C16:0), stearic (C18:0), arachidic (C20:0) and docosanic (C22:0), TNFα, IL-1β, IL-6, IL-8, C-reactive protein, cholesterol, triglycerides, HDL, and LPO intensity were measured. In patients with coronary atherosclerosis, increased concentrations of saturated fatty acids, triglycerides, LPO products, IL-6, IL-8, and C-reactive protein were found. Correlation analysis revealed multiple correlations between the studied fatty acids, correlation of C16:0, C18:0, and C20:0 with inflammation markers, C14:0, C16:0, and C18:0 with triglyceride level, C16:0, C18:0, and C20:0 with cholesterol. The contents of C14:0, C15:0, C16:0, and C18:0 correlated with the presence of coronary atherosclerosis. Lipid metabolism disturbances in coronary atherosclerosis were accompanied by changes in not only lipid spectrum and inflammation markers, but also fatty acids balance.
About the authors
Ya. V. Polonskaya
Research Institute of Therapy and Preventive Medicine
Author for correspondence.
Email: yana-polonskaya@yandex.ru
Russian Federation, Novosibirsk
V. S. Shramko
Research Institute of Therapy and Preventive Medicine
Email: yana-polonskaya@yandex.ru
Russian Federation, Novosibirsk
S. V. Morozov
N. N. Vorozhtsov Novosibirsk State University of Organic Chemistry
Email: yana-polonskaya@yandex.ru
Russian Federation, Novosibirsk
E. I. Chernyak
N. N. Vorozhtsov Novosibirsk State University of Organic Chemistry
Email: yana-polonskaya@yandex.ru
Russian Federation, Novosibirsk
A. M. Chernyavsky
E.N. Meshalkin Siberian Federal Biomedical Research Center, Ministry of Health of the Russian Federation
Email: yana-polonskaya@yandex.ru
Russian Federation, Novosibirsk
Y. I. Ragino
Research Institute of Therapy and Preventive Medicine
Email: yana-polonskaya@yandex.ru
Russian Federation, Novosibirsk