Role of Endogenous Agonists of Opioid Receptors in the Regulation of Heart Resistance to Postischemic Reperfusion Injury
- Authors: Gorbunov A.S.1, Vaizova O.E.2, Belousov M.V.2, Pozdnyakova S.V.3, Nesterov E.A.4, Madonov P.G.3
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Affiliations:
- Research Institute of Cardiology, Tomsk Research Center, Russian Academy of Sciences
- Siberian State Medical University, Ministry of Health of the Russian Federation
- Novosibirsk State Medical University, Ministry of Health of the Russian Federation
- National Research Tomsk Polytechnic University
- Issue: Vol 164, No 1 (2017)
- Pages: 18-20
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239326
- DOI: https://doi.org/10.1007/s10517-017-3916-6
- ID: 239326
Cite item
Abstract
Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective μ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.
About the authors
A. S. Gorbunov
Research Institute of Cardiology, Tomsk Research Center, Russian Academy of Sciences
Author for correspondence.
Email: barabator@sibmail.com
Russian Federation, Tomsk
O. E. Vaizova
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: barabator@sibmail.com
Russian Federation, Tomsk
M. V. Belousov
Siberian State Medical University, Ministry of Health of the Russian Federation
Email: barabator@sibmail.com
Russian Federation, Tomsk
S. V. Pozdnyakova
Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: barabator@sibmail.com
Russian Federation, Novosibirsk
E. A. Nesterov
National Research Tomsk Polytechnic University
Email: barabator@sibmail.com
Russian Federation, Tomsk
P. G. Madonov
Novosibirsk State Medical University, Ministry of Health of the Russian Federation
Email: barabator@sibmail.com
Russian Federation, Novosibirsk