Effect of Lipid Surface Composition on the Formation and Structure of Fibrin Clots
- Authors: Bakirova D.R.1, Faizullin D.A.1, Valiullina Y.A.1, Salnikov V.V.1, Zuev Y.F.1
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Affiliations:
- Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Science
- Issue: Vol 163, No 6 (2017)
- Pages: 722-725
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/239218
- DOI: https://doi.org/10.1007/s10517-017-3889-5
- ID: 239218
Cite item
Abstract
We studied the influence of lipid surface composition on the kinetics of fibrin clot formation and its structure. It was shown that lipid surface affects all phases of fibrin polymerization and chances clot morphology. The magnitude and character of the effect depend on the charge and phase state of lipids that determine the interaction of fibrinogen with the lipid surface and its conformational changes, which modulated the process of fibrinogen conversion into fibrin and, as a result, the formation and morphology of the fibrin clot.
About the authors
D. R. Bakirova
Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Science
Author for correspondence.
Email: bakirova.dilyafruz@gmail.com
Russian Federation, Kazan
D. A. Faizullin
Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Science
Email: bakirova.dilyafruz@gmail.com
Russian Federation, Kazan
Yu. A. Valiullina
Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Science
Email: bakirova.dilyafruz@gmail.com
Russian Federation, Kazan
V. V. Salnikov
Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Science
Email: bakirova.dilyafruz@gmail.com
Russian Federation, Kazan
Yu. F. Zuev
Kazan Institute of Biochemistry and Biophysics, Kazan Research Center, Russian Academy of Science
Email: bakirova.dilyafruz@gmail.com
Russian Federation, Kazan