Email this article Changes in the Proteome of HaCaT Keratinocytes Induced by Cytotoxic Substance Triton X-100
- Authors: Poverennaya E.V.1, Petushkova N.A.1, Luzgina N.G.1, Rusanov A.L.2, Nakhod K.V.1, Nakhod V.I.1
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Affiliations:
- V. N. Orekhovich Research Institute of Biomedical Chemistry
- Perspective Company
- Issue: Vol 163, No 5 (2017)
- Pages: 620-622
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/239130
- DOI: https://doi.org/10.1007/s10517-017-3863-2
- ID: 239130
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Abstract
Changes in the proteome of keratinocytes of immortalized HaCaT line exposed to cytotoxic substance Triton X-100 in concentrations of 12.5 and 25 μg/ml were studied by liquid chromatography combined with mass spectrometry. The appearance of proteins involved in the regulation of mitosis, RNA stability, and catabolic processes were detected; the number of apoptosis-associated proteins increased, while the number of proteins involved in differentiation and energy metabolism of keratinocytes decreased.
About the authors
E. V. Poverennaya
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: alexander.l.rusanov@gmail.com
Russian Federation, Moscow
N. A. Petushkova
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: alexander.l.rusanov@gmail.com
Russian Federation, Moscow
N. G. Luzgina
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: alexander.l.rusanov@gmail.com
Russian Federation, Moscow
A. L. Rusanov
Perspective Company
Author for correspondence.
Email: alexander.l.rusanov@gmail.com
Russian Federation, Novosibirsk
K. V. Nakhod
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: alexander.l.rusanov@gmail.com
Russian Federation, Moscow
V. I. Nakhod
V. N. Orekhovich Research Institute of Biomedical Chemistry
Email: alexander.l.rusanov@gmail.com
Russian Federation, Moscow
