Expression of Signal Molecules in Culture of Human Endothelial Cells in Atherosclerosis and Restenosis
- Authors: Kozlov K.L.1, Bolotov I.I.1, Lin’kova N.S.1,2, Drobintseva A.O.3
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Affiliations:
- St. Petersburg Institute of Bioregulation and Gerontology
- Peter the Great St. Petersburg Polytechnic University
- D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
- Issue: Vol 163, No 4 (2017)
- Pages: 566-569
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/239093
- DOI: https://doi.org/10.1007/s10517-017-3850-7
- ID: 239093
Cite item
Abstract
We compared the expression of signal molecules in the culture of human endothelial cells under normal conditions and in atherosclerosis and restenosis. Expression of connexin-37 and sirtuin-1 in atherosclerosis and restenosis surpassed the normal by 2 and 5 times, respectively, and expression of endothelin-1 3-fold surpassed the normal. In restenosis, changes in the expression connexin-37 and endothelin-1 became more pronounced in comparison with atherosclerosis. Connexin-37 and endothelin-1 can serve as predictive markers for prognosis of post-stenting complications in patients with atherosclerosis.
About the authors
K. L. Kozlov
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
I. I. Bolotov
St. Petersburg Institute of Bioregulation and Gerontology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg
N. S. Lin’kova
St. Petersburg Institute of Bioregulation and Gerontology; Peter the Great St. Petersburg Polytechnic University
Author for correspondence.
Email: miayy@yandex.ru
Russian Federation, St. Petersburg; St. Petersburg
A. O. Drobintseva
D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology
Email: miayy@yandex.ru
Russian Federation, St. Petersburg