Changes in the Activity of Proteasomes and Calpains in Metastases of Human Lung Cancer and Breast Cancer
- Authors: Shashova E.E.1, Kolegova E.S.1, Zav’yalov A.A.1, Slonimskaya E.M.1, Kondakova I.V.1
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Affiliations:
- Tomsk National Research Medical Center, Russian Academy of Sciences
- Issue: Vol 163, No 4 (2017)
- Pages: 486-489
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/239017
- DOI: https://doi.org/10.1007/s10517-017-3834-7
- ID: 239017
Cite item
Abstract
In patients with breast cancer and lung cancer, chymotrypsin-like and caspase-like activities of proteasomes and total activity of calpains in the primary tumor nodes and lymphogenic metastasis are elevated in comparison with the corresponding normal tissues. The development of lymphogenic metastases of breast cancer and lung cancer was associated with opposite change in caspase-like activity of proteasomes. These results can be useful for the development of methods for evaluation of aggressiveness of breast and lung cancer.
About the authors
E. E. Shashova
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: kondakova@onkology.tomsk.ru
Russian Federation, Tomsk
E. S. Kolegova
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: kondakova@onkology.tomsk.ru
Russian Federation, Tomsk
A. A. Zav’yalov
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: kondakova@onkology.tomsk.ru
Russian Federation, Tomsk
E. M. Slonimskaya
Tomsk National Research Medical Center, Russian Academy of Sciences
Email: kondakova@onkology.tomsk.ru
Russian Federation, Tomsk
I. V. Kondakova
Tomsk National Research Medical Center, Russian Academy of Sciences
Author for correspondence.
Email: kondakova@onkology.tomsk.ru
Russian Federation, Tomsk