Email this article The Effectiveness of Cyclic Hydroxamic Acid CHA-5 against Drug-Resistant P388 Leukemia Strains
- Authors: Goncharova S.A.1, Vystorop I.V.1, Raevskaya T.A.1, Konovalova N.P.1
-
Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Issue: Vol 163, No 3 (2017)
- Pages: 385-388
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238925
- DOI: https://doi.org/10.1007/s10517-017-3810-2
- ID: 238925
Cite item
Open Access
Access granted
Subscription Access
Abstract
We studied the effectiveness of cyclic hydroxamic acid CHA-5 against drug-resistant and multidrug-resistant murine P388 leukemia strains. More than 60% mice receiving transplantation of rubomycin-resistant leukemia P388 strain survived after CHA-5 monotherapy; combined therapy with CHA-5 and cisplatin was also highly effective. Vincristine-resistant tumor was highly sensitive to combined treatment with CHA-5 and cyclophosphamide. It should be emphasized that standard antitumor agents were used in very low doses in combination therapy and CHA-5 significantly potentiated their effect.
About the authors
S. A. Goncharova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: sago@icp.ac.ru
Russian Federation, Chernogolovka, Moscow region
I. V. Vystorop
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sago@icp.ac.ru
Russian Federation, Chernogolovka, Moscow region
T. A. Raevskaya
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sago@icp.ac.ru
Russian Federation, Chernogolovka, Moscow region
N. P. Konovalova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sago@icp.ac.ru
Russian Federation, Chernogolovka, Moscow region
