High Antimetastatic Activity of Platin Liposomal Form after Lyophilization and Storage
- Authors: Kaledin V.I.1, Nikolin V.P.1, Popova N.A.1,2, Klinnikova M.G.3, Bogdanova L.A.3, Morozkova T.S.3
-
Affiliations:
- Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Novosibirsk National Research State University
- Institute of Molecular Pathology and Pathomorphology
- Issue: Vol 163, No 3 (2017)
- Pages: 349-351
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238882
- DOI: https://doi.org/10.1007/s10517-017-3801-3
- ID: 238882
Cite item
Abstract
Antimetastatic activity of Platin in lyophilized liposomes stored for 7 years after fabrication was evaluated. The main flaw of liposomes as vehicles for drug delivery to the tumors is their high affinity for the liver, which accumulates a great amount thereof. This property of liposomes can be used for adjuvant therapy of operable primary tumors metastasizing to the liver. It is shown on the model of mouse GA-1 tumor metastases in the liver that platinum(II) complex compound Platin in phosphatidylcholine-cholesterol liposomes, stored for 7 years after lyophilization, causes complete cure of 40% animals, while free Platin prolongs the lifespan of mice with tumors by only 31.7% vs. control (no treatment).
About the authors
V. I. Kaledin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Author for correspondence.
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
V. P. Nikolin
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
N. A. Popova
Federal Research Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences; Novosibirsk National Research State University
Email: pathol@inbox.ru
Russian Federation, Novosibirsk; Novosibirsk
M. G. Klinnikova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
L. A. Bogdanova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk
T. S. Morozkova
Institute of Molecular Pathology and Pathomorphology
Email: pathol@inbox.ru
Russian Federation, Novosibirsk