Association of Level of Proprotein Convertase Subtilisin/Kexin Type 9 with Intima-Media Thickness in Patients with Familial Hypercholesterolemia
- Authors: Benimetskaya K.S.1, Ragino Y.I.1, Shakhtshneider E.V.1, Makarenkova K.V.1, Shchepina Y.V.1, Stakhneva E.M.1, Voevoda M.I.1
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Affiliations:
- Research Institute of Internal and Preventive Medicine
- Issue: Vol 163, No 2 (2017)
- Pages: 199-202
- Section: Biophysics and Biochemistry
- URL: https://journals.rcsi.science/0007-4888/article/view/238749
- DOI: https://doi.org/10.1007/s10517-017-3765-3
- ID: 238749
Cite item
Abstract
We studied association of PCSK9 protein with the carotid artery intima-media thickness in patients with familial hypercholesterolemia (N=53; age 49.9±6.9 years) treated with statins. Blood level of PCSK9 protein was measured by ELISA; ultrasonography of the carotid arteries with measurement of the thickness of the intima-media complex of the common carotid arteries in the distal segment for 10 mm from the bifurcation on the far wall of the vessel was performed in on-line mode. The mean values were calculated for both sides, the maximum mean value was included in the analysis. It was shown that PCSK9 levels positively correlate with carotid artery intima-media thickness in patients with familial hypercholesterolemia.
About the authors
K. S. Benimetskaya
Research Institute of Internal and Preventive Medicine
Author for correspondence.
Email: benimetskaya@gmail.com
Russian Federation, Novosibirsk
Yu. I. Ragino
Research Institute of Internal and Preventive Medicine
Email: benimetskaya@gmail.com
Russian Federation, Novosibirsk
E. V. Shakhtshneider
Research Institute of Internal and Preventive Medicine
Email: benimetskaya@gmail.com
Russian Federation, Novosibirsk
K. V. Makarenkova
Research Institute of Internal and Preventive Medicine
Email: benimetskaya@gmail.com
Russian Federation, Novosibirsk
Yu. V. Shchepina
Research Institute of Internal and Preventive Medicine
Email: benimetskaya@gmail.com
Russian Federation, Novosibirsk
E. M. Stakhneva
Research Institute of Internal and Preventive Medicine
Email: benimetskaya@gmail.com
Russian Federation, Novosibirsk
M. I. Voevoda
Research Institute of Internal and Preventive Medicine
Email: benimetskaya@gmail.com
Russian Federation, Novosibirsk