Effect of Peripheral μ-, δ-, and κ-Opioid Ligands on the Development of Tolerance to Ethanol-Induced Analgesia
- Authors: Sudakov S.K.1, Alekseeva E.V.1, Nazarova G.A.1
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Affiliations:
- P. K. Anokhin Research Institute of Normal Physiology
- Issue: Vol 163, No 2 (2017)
- Pages: 177-179
- Section: Physiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238736
- DOI: https://doi.org/10.1007/s10517-017-3760-8
- ID: 238736
Cite item
Abstract
We studied the rate of development of tolerance to the ethanol-induced analgesia under the effect of μ-, δ-, and κ-opioid agonists and antagonists not crossing the blood-brain barrier and rapidly inactivated by gastric and duodenal proteolytic enzymes. Activation of gastric κ-opioid receptors eliminated the analgesic effect of ethanol and accelerated the development of tolerance to ethanol-induced analgesia. In contrast, activation of gastric μ-opioid receptors decelerated the development of this tolerance. Activation of gastric δ-opioid receptors produced no effect on examined tolerance. μ-Opioid receptor antagonist decelerated and δ-opioid receptor antagonist accelerated the development of tolerance to ethanol-induced analgesia. Thus, the state of gastric opioid receptors affects the manifestation of ethanol-induced analgesia and the development of tolerance to this effect.
About the authors
S. K. Sudakov
P. K. Anokhin Research Institute of Normal Physiology
Author for correspondence.
Email: s-sudakov@nphys.ru
Russian Federation, Moscow
E. V. Alekseeva
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Russian Federation, Moscow
G. A. Nazarova
P. K. Anokhin Research Institute of Normal Physiology
Email: s-sudakov@nphys.ru
Russian Federation, Moscow