Email this article Toxic Effects of Nanostructured Silicon Dioxide on Multipotent Mesenchymal Stromal Cells
- Authors: Lykov A.P.1,2, Lykova Y.A.3, Poveshchenko O.V.1,2, Bondarenko N.A.1,2, Surovtseva M.A.1,2, Bgatova N.P.1, Konenkov V.I.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology
- E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
- Novosibirsk State Technical University
- Issue: Vol 163, No 1 (2017)
- Pages: 159-162
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/238721
- DOI: https://doi.org/10.1007/s10517-017-3757-3
- ID: 238721
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Abstract
We studied the effect of nanostructured silicon dioxide particles on functional activity and ultrastructure of rat multipotent mesenchymal stem cells. A dose-dependent decrease in cell adhesion to plastics and their proliferative potential, accumulation of apoptotic cells, a decrease in the electron density of cell cytoplasm due to swelling and degenerative changes of organelles, and intracellular accumulation of nanostructured of silicon dioxide particles were observed.
About the authors
A. P. Lykov
Research Institute of Clinical and Experimental Lymphology; E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Author for correspondence.
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
Yu. A. Lykova
Novosibirsk State Technical University
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
O. V. Poveshchenko
Research Institute of Clinical and Experimental Lymphology; E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
N. A. Bondarenko
Research Institute of Clinical and Experimental Lymphology; E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
M. A. Surovtseva
Research Institute of Clinical and Experimental Lymphology; E. N. Meshalkin Novosibirsk Research Institute of Circulation Pathology
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
N. P. Bgatova
Research Institute of Clinical and Experimental Lymphology
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
V. I. Konenkov
Research Institute of Clinical and Experimental Lymphology
Email: aplykov2@mail.ru
Russian Federation, Novosibirsk
