Design of Chemical Conjugate for Targeted Therapy of Multiple Sclerosis Based of Constant Fragment of Human Antibody Heavy Chain and Peptoid Analog of Autoantigen MOG35-55
- Authors: Lomakin Y.A.1, Stepanov A.V.1, Balabashin D.S.1, Ponomarenko N.A.1, Smirnov I.V.1, Belogurov A.A.1
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Affiliations:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences
- Issue: Vol 162, No 6 (2017)
- Pages: 777-780
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238555
- DOI: https://doi.org/10.1007/s10517-017-3711-4
- ID: 238555
Cite item
Abstract
Elimination of B cells producing autoantibodies to neuroantigens is considered as beneficial in the treatment of multiple sclerosis. Myelin oligodendrocyte glycoprotein (MOG) is a significant autoantigen in multiple sclerosis. It was shown that MOG-like peptoid AMogP3 can bind autoantibodies produced by pathological lymphocytes. We propose a structure of an innovative drug for targeted elimination of the pool of autoreactive B cells responsible for multiple sclerosis pathogenesis; this compound is a complex of peptoid AMogP3 with Fc fragment of human immunoglobulin. The obtained Fc-PEG-AMogP3 conjugate effectively interact with autoreactive antibodies, which attests to their high therapeutic potential.
About the authors
Y. A. Lomakin
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences
Email: alexey.belogurov.jr@gmail.com
Russian Federation, Moscow
A. V. Stepanov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences
Email: alexey.belogurov.jr@gmail.com
Russian Federation, Moscow
D. S. Balabashin
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences
Email: alexey.belogurov.jr@gmail.com
Russian Federation, Moscow
N. A. Ponomarenko
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences
Email: alexey.belogurov.jr@gmail.com
Russian Federation, Moscow
I. V. Smirnov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences
Email: alexey.belogurov.jr@gmail.com
Russian Federation, Moscow
A. A. Belogurov
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences
Author for correspondence.
Email: alexey.belogurov.jr@gmail.com
Russian Federation, Moscow