Effect of Nerve Growth Factor on Neural Differentiation of Mouse Embryonic Stem Cells
- Authors: Antonov S.A.1, Manuilova E.S.1, Dolotov O.V.1, Kobylyansky A.G.1, Safina D.R.1, Grivennikov I.A.1
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Affiliations:
- Institute of Molecular Genetics, Russian Academy of Sciences
- Issue: Vol 162, No 5 (2017)
- Pages: 679-683
- Section: Experimental Biology
- URL: https://journals.rcsi.science/0007-4888/article/view/238462
- DOI: https://doi.org/10.1007/s10517-017-3686-1
- ID: 238462
Cite item
Abstract
The cholinergic, GABAergic, and catecholaminergic neurons derived from mouse embryonic stem cells in a culture medium supplemented with recombinant NGF were phenotyped and scored. NGF stimulated generation of neurons, but not neuronal progenitors from embryonic stem cells and affected the proportion of specific types of neurons in cultures of differentiating embryonic stem cells. These findings open vista to employ NGF for generation of specific neuron types from embryonic stem cells for fundamental and toxicological studies.
About the authors
S. A. Antonov
Institute of Molecular Genetics, Russian Academy of Sciences
Author for correspondence.
Email: vamore@inbox.ru
Russian Federation, Moscow
E. S. Manuilova
Institute of Molecular Genetics, Russian Academy of Sciences
Email: vamore@inbox.ru
Russian Federation, Moscow
O. V. Dolotov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: vamore@inbox.ru
Russian Federation, Moscow
A. G. Kobylyansky
Institute of Molecular Genetics, Russian Academy of Sciences
Email: vamore@inbox.ru
Russian Federation, Moscow
D. R. Safina
Institute of Molecular Genetics, Russian Academy of Sciences
Email: vamore@inbox.ru
Russian Federation, Moscow
I. A. Grivennikov
Institute of Molecular Genetics, Russian Academy of Sciences
Email: vamore@inbox.ru
Russian Federation, Moscow