Role of Prolactin in the Regulation of Bicarbonates Biodynamics in Female Rat Model of Cholestasis of Pregnancy
- Authors: Bulaeva O.A.1, Abramicheva P.A.1, Balakina T.A.1, Smirnova O.V.1
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Affiliations:
- Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University
- Issue: Vol 162, No 5 (2017)
- Pages: 611-614
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238406
- DOI: https://doi.org/10.1007/s10517-017-3669-2
- ID: 238406
Cite item
Abstract
We studied possible involvement of prolactin in the regulation of bicarbonate biodynamics using female rat model of cholestasis of pregnancy induced by transplantation of the donor pituitary under the renal capsule of a recipient (hyperprolactinemia) and bile duct ligation (cholestasis). The concentration of bicarbonates in the bile and blood, their excretion, clearance, and reabsorption, as well as glomerular filtration rate and excretion of sodium ions were assessed. It was found that the main effect of prolactin was directed to the kidney-regulated pool of bicarbonates and consisted in stimulation of their clearance and inhibition of reabsorption, which led to a decrease in bicarbonate blood concentration. Parallel influence of prolactin on the clearance of bicarbonates and sodium ions was observed.
About the authors
O. A. Bulaeva
Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University
Email: smirnova_ov@mail.ru
Russian Federation, Moscow
P. A. Abramicheva
Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University
Email: smirnova_ov@mail.ru
Russian Federation, Moscow
T. A. Balakina
Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University
Email: smirnova_ov@mail.ru
Russian Federation, Moscow
O. V. Smirnova
Laboratory of Endocrinology, Biological Faculty, M. V. Lomonosov Moscow State University
Author for correspondence.
Email: smirnova_ov@mail.ru
Russian Federation, Moscow