Effect of Successive Administration of Vancomycin and Amikacin on Auditory Function of Immature Animals
- Authors: D’yakonova I.N.1, Kamkina O.V.1, Rakhmanova I.V.1, Ishanova Y.S.1, Burmistrova D.S.1
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Affiliations:
- N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation
- Issue: Vol 162, No 4 (2017)
- Pages: 458-461
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238297
- DOI: https://doi.org/10.1007/s10517-017-3639-8
- ID: 238297
Cite item
Abstract
Effect of successive administration vancomycin and amikacin in therapeutic doses on immature auditory organ was compared to single administration of the same drugs in chronic experiments on immature rabbits by recording of short-latency auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Drug administration always increased significantly the ABR peak I threshold. Ototoxic antibiotics did not change DPOAE, but selectively affected activity of outer hair cells. No enhancement of the ototoxic effects was observed after successive administration of the two antibiotics.
About the authors
I. N. D’yakonova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation
Email: 5342748@mail.ru
Russian Federation, Moscow
O. V. Kamkina
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation
Email: 5342748@mail.ru
Russian Federation, Moscow
I. V. Rakhmanova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation
Email: 5342748@mail.ru
Russian Federation, Moscow
Yu. S. Ishanova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation
Email: 5342748@mail.ru
Russian Federation, Moscow
D. S. Burmistrova
N. I. Pirogov Russian National Research Medical University, Ministry of Health of Russian Federation
Author for correspondence.
Email: 5342748@mail.ru
Russian Federation, Moscow