NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats
- Authors: Masliuko P.M.1, Anikina T.A.2, Zverev A.A.2, Krylova A.V.2, Moiseev K.Y.1, Zefirov T.L.2
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Affiliations:
- Department of Normal Physiology and Biophysics, Yaroslavl State Medical University
- Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
- Issue: Vol 162, No 4 (2017)
- Pages: 418-420
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/238272
- DOI: https://doi.org/10.1007/s10517-017-3629-x
- ID: 238272
Cite item
Abstract
Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10—7 M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY1 receptors in myocardial contraction.
About the authors
P. M. Masliuko
Department of Normal Physiology and Biophysics, Yaroslavl State Medical University
Email: alekcei5@rambler.ru
Russian Federation, Yaroslavl
T. A. Anikina
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Email: alekcei5@rambler.ru
Russian Federation, Kazan
A. A. Zverev
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Author for correspondence.
Email: alekcei5@rambler.ru
Russian Federation, Kazan
A. V. Krylova
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Email: alekcei5@rambler.ru
Russian Federation, Kazan
K. Yu. Moiseev
Department of Normal Physiology and Biophysics, Yaroslavl State Medical University
Email: alekcei5@rambler.ru
Russian Federation, Yaroslavl
T. L. Zefirov
Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University
Email: alekcei5@rambler.ru
Russian Federation, Kazan