Effects of Deltorphin II and Its Retroenantio Analog on Cardiac Tolerance to Ischemia and Reperfusion
- Authors: Mukhomedzyanov A.V.1, Maslov L.N.1, Ovchinnikov M.V.2, Sidorova M.V.2, Pei J.M.3, Tsibul’nikov S.Y.1, Tsepokina A.V.1, Khutornaya M.V.1, Kutikhin A.G.1
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Affiliations:
- Research Institute of Cardiology
- Peptide Synthesis Company
- Fourth Military Medical University
- Issue: Vol 162, No 3 (2017)
- Pages: 306-309
- Section: General Pathology and Pathophysiology
- URL: https://journals.rcsi.science/0007-4888/article/view/238150
- DOI: https://doi.org/10.1007/s10517-017-3601-9
- ID: 238150
Cite item
Abstract
Selective agonist of δ2-opioid receptors deltorphin II and its retroenantio analog (0.12 mg/kg intravenously) were preventively injected to male Wistar rats 15 min prior to 45-min coronary occlusion or 5 min before 120-min reperfusion. Administration of deltorphin II before artery occlusion and before reperfusion decreased the infarct size/area at risk ratio. Deltorphin II prevented the appearance of ischemia-provoked ventricular arrhythmias and exerted no effect on HR and BP (systolic and diastolic). The retroenantio analog of deltorphin II produced no antiarrhythmic or infarct-limiting effects, but reduced HR without affecting BP. Deltorphin II can be viewed as a promising prototype for a medicinal remedy to treat acute myocardial infarction.
About the authors
A. V. Mukhomedzyanov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
L. N. Maslov
Research Institute of Cardiology
Author for correspondence.
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
M. V. Ovchinnikov
Peptide Synthesis Company
Email: maslov@cardio-tomsk.ru
Russian Federation, Moscow
M. V. Sidorova
Peptide Synthesis Company
Email: maslov@cardio-tomsk.ru
Russian Federation, Moscow
J. M. Pei
Fourth Military Medical University
Email: maslov@cardio-tomsk.ru
China, Xi’an, Shaanxi Province
S. Yu. Tsibul’nikov
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
A. V. Tsepokina
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
M. V. Khutornaya
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk
A. G. Kutikhin
Research Institute of Cardiology
Email: maslov@cardio-tomsk.ru
Russian Federation, Tomsk