Involvement of JAK1, JAK2, and JAK3 in Stimulation of Functional Activity of Mesenchymal Progenitor Cells by Fibroblast Growth Factor
- Authors: Zyuz’kov G.N.1,2, Zhdanov V.V.1, Udut E.V.1, Miroshnichenko L.A.1, Simanina E.V.1, Polyakova T.Y.1, Stavrova L.A.1, Udut V.V.1,2, Minakova M.Y.1, Dygai A.M.1
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Affiliations:
- E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
- National Research Tomsk State University
- Issue: Vol 162, No 2 (2016)
- Pages: 240-243
- Section: Microbiology and Immunology
- URL: https://journals.rcsi.science/0007-4888/article/view/238079
- DOI: https://doi.org/10.1007/s10517-016-3585-x
- ID: 238079
Cite item
Abstract
We studied the involvement of individual JAK kinases in the realization of the growth potential of mesenchymal precursors under the effect of fibroblast growth factor. The important role of JAK2 and JAK3 in determining the initial level of mitotic activity of progenitor cells and participation of JAK1 in this process under conditions of cytokine stimulation of progenitor cells were demonstrated. Specific inhibitors of these kinases reduced the yield of fibroblast CFU and the rate of their division. Moreover, blockade of JAK1, JAK2, and JAK3 under the effect of fibroblast growth factor was accompanied by an increase in the intensity of progenitor cell differentiation.
About the authors
G. N. Zyuz’kov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; National Research Tomsk State University
Author for correspondence.
Email: zgn@pharmso.ru
Russian Federation, Tomsk; Tomsk
V. V. Zhdanov
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
E. V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
L. A. Miroshnichenko
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
E. V. Simanina
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
T. Yu. Polyakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
L. A. Stavrova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
V. V. Udut
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine; National Research Tomsk State University
Email: zgn@pharmso.ru
Russian Federation, Tomsk; Tomsk
M. Yu. Minakova
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk
A. M. Dygai
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
Email: zgn@pharmso.ru
Russian Federation, Tomsk