Effect of ICa,L Blockade on Adrenergic Stimulation in Developing Heart
- Authors: Zefirov T.L.1, Kuptsova A.M.1, Biktemirova R.G.1, Ziyatdinova N.I.1, Zefirov A.L.2
-
Affiliations:
- Department of Human Health Protection, Kazan (Volga Region) Federal University
- Department of Normal Physiology, Kazan StateMedical University
- Issue: Vol 161, No 6 (2016)
- Pages: 746-748
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237745
- DOI: https://doi.org/10.1007/s10517-016-3500-5
- ID: 237745
Cite item
Abstract
The effect of verapamil-induced blockade of L-type calcium ionic currents (ICa,L) on the action of non-selective adrenergic cardiac stimulation by norepinephrine was examined during different periods of early postnatal ontogeny. In 1-week-old rats, intravenous norepinephrine induced a short-term tachycardia both with and without preliminary injected verapamil. In 3-week-old rats, norepinephrine alone produced no chronotropic effect; in contrast, it induced a biphasic tachycardia in verapamil-treated rats. In 6- and 20-month-old rats, norepinephrine induced a short-term tachycardia, which could be prevented by verapamil. The age-related peculiarities of chronotropic action of non-selective adrenergic stimulation are indicative of the role of L-type calcium ionic channels in the development of sympathetic control over the heart.
About the authors
T. L. Zefirov
Department of Human Health Protection, Kazan (Volga Region) Federal University
Author for correspondence.
Email: zefirovtl@mail.ru
Russian Federation, Kazan
A. M. Kuptsova
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
R. G. Biktemirova
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
N. I. Ziyatdinova
Department of Human Health Protection, Kazan (Volga Region) Federal University
Email: zefirovtl@mail.ru
Russian Federation, Kazan
A. L. Zefirov
Department of Normal Physiology, Kazan StateMedical University
Email: zefirovtl@mail.ru
Russian Federation, Kazan, the Republic of Tatarstan