Effect of Hyperlipidemia and Plasma Cytokine Levels in Rats after Anterior Abdominal Wall Reconstruction with the Use of Synthetic Endoprostheses

Abstract

The effect of hyperlipidemia on the systemic production of cytokines was evaluated in the plasma of rats after anterior abdominal wall reconstruction with polypropylene (Esfil) and polytetrafluorethylene (Ecoflon) endoprostheses. The reference group was formed from animals without hyperlipidemia, in which anterior abdominal wall plasty was carried out with the use of the same endoprostheses. Intact rats without hyperlipidemia and intervention served as the control. Hypercytokinemia was detected on days 1-10 after reconstructive surgery on the anterior abdominal wall. Polytetrafluoroethylene alloplasty was associated with higher plasma production of pro- and anti-inflammatory cytokines, which characterized mainly the implant reactogenicity. Hyperlipidemia modified the reactivity of immunocompetent cells to the endoprosthesis. A progressive decrease in the content of proinflammatory cytokines (IL-1β and TNF-α) was observed by day 10 after endoprosthesis implantation, this decrease being more manifest in response to polytetrafluoroethylene. High plasma levels of pro- and antiinflammatory cytokines (IL-1β, INF-α, IFN-γ, and IL-10) were detected in hyperlipidemic rats on day 1 after polypropylene plasty; by day 10, the plasma level of IFN-γ increased, which reflected positive activation of Th1 lymphocytes.