Email this article Biochemical Changes in Erythrocytes as a Molecular Marker of Cell Damage during Long-Term Simvastatin Treatment
- Authors: Mikashinovich Z.I.1, Belousova E.S.2
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Affiliations:
- Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation
- Department of Pharmaceutical Chemistry and Pharmacology, Rostov State Medical University, Ministry of Health of the Russian Federation
- Issue: Vol 161, No 4 (2016)
- Pages: 600-603
- Section: Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
- URL: https://journals.rcsi.science/0007-4888/article/view/237613
- DOI: https://doi.org/10.1007/s10517-016-3467-2
- ID: 237613
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Abstract
Long-term administration of simvastatin to rats, irrespective of the baseline cholesterol levels, induced biochemical changes in erythrocytes attesting to hypoxic damage (accumulation of lactate and 2,3-diphosphoglycerate), disturbances in ATP-dependent mechanisms of ion homeostasis regulation (decrease in total ATPase and Ca2+-ATPase activities), and antioxidant enzymes system imbalance. These changes can be considered as a sensitive indicator and molecular basis of cell damage during long-term administration of statins.
About the authors
Z. I. Mikashinovich
Department of General and Clinical Biochemistry No. 1, Rostov State Medical University, Ministry of Health of the Russian Federation
Email: belousovalena@mail.ru
Russian Federation, Rostov-on-Don
E. S. Belousova
Department of Pharmaceutical Chemistry and Pharmacology, Rostov State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: belousovalena@mail.ru
Russian Federation, Rostov-on-Don
