Email this article Antiproliferative Effects of Modified Bioflavonoid in Ex Vivo Model
- Authors: Albegova D.Z.1, Kamkina O.V.1, Pavlova S.I.2, Albegova Z.K.3, Laptev O.S.1, Kozlov I.G.1
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Affiliations:
- Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
- N. I. Ul’yanov Chuvash State University
- North Ossetian State Medical Academy, Ministry of Health of Russia
- Issue: Vol 161, No 3 (2016)
- Pages: 381-383
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237440
- DOI: https://doi.org/10.1007/s10517-016-3419-x
- ID: 237440
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Abstract
We studied the effect of modified bioflavonoid and reference drug quercetin dihydrate on proliferation of mononuclears triggered by T- and B-cell mitogens. Lymphocytes were in vivo pretreated with the examined agents followed by their explantation and in vitro activation with T- and B-cell mitogens in cell culture. Intraperitoneal injection of modified bioflavonoid and quercetin dihydrate produced a dose-dependent inhibition of proliferation of the in vitroactivated splenocytes; modified bioflavonoid demonstrated higher antiproliferative activity.
About the authors
D. Z. Albegova
Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: bigbeaver-90@mail.ru
Russian Federation, Moscow
O. V. Kamkina
Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: bigbeaver-90@mail.ru
Russian Federation, Moscow
S. I. Pavlova
N. I. Ul’yanov Chuvash State University
Email: bigbeaver-90@mail.ru
Russian Federation, Cheboksary, Chuvash Republic
Zh. K. Albegova
North Ossetian State Medical Academy, Ministry of Health of Russia
Author for correspondence.
Email: bigbeaver-90@mail.ru
Russian Federation, Vladikavkaz, The Republic of North Ossetia-Alania
O. S. Laptev
Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: bigbeaver-90@mail.ru
Russian Federation, Moscow
I. G. Kozlov
Department of Pharmacology, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation
Email: bigbeaver-90@mail.ru
Russian Federation, Moscow
