Effect of Afobazole and Betaine on Cognitive Disorders in the Offspring of Rats with Streptozotocin-Induced Diabetes and Their Relationship with DNA Damage
- Authors: Zabrodina V.V.1, Shreder O.V.1, Shreder E.D.1, Durnev A.D.1
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Affiliations:
- V. V. Zakusov Research Institute of Pharmacology
- Issue: Vol 161, No 3 (2016)
- Pages: 359-366
- Section: Pharmacology and Toxicology
- URL: https://journals.rcsi.science/0007-4888/article/view/237419
- DOI: https://doi.org/10.1007/s10517-016-3414-2
- ID: 237419
Cite item
Abstract
Cognitive activity in 60-day-old offspring of rats (intrauterine development in experimental streptozotocin-induced diabetes) was studied on the model of food-seeking behavior under conditions of free choice in a 6-arm maze. The formation of the food-procuring skill was significantly delayed, which attests to impairment of cognitive functions in these animals. Peroral administration of afobazole (10 and 50 mg/kg) and betaine (50 and 100 mg/kg) significantly and dose-dependently alleviated this disorder. Correlation analysis of the data on delayed formation of a food-procuring skill and results of DNA comet attests to a strong relationship between DNA damage in cells of the embryo and placenta during intrauterine development and cognitive dysfunction in the postnatal offspring of animals with streptozotocin-induced diabetes.
About the authors
V. V. Zabrodina
V. V. Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: zabrodinavv@gmail.com
Russian Federation, Moscow
O. V. Shreder
V. V. Zakusov Research Institute of Pharmacology
Email: zabrodinavv@gmail.com
Russian Federation, Moscow
E. D. Shreder
V. V. Zakusov Research Institute of Pharmacology
Email: zabrodinavv@gmail.com
Russian Federation, Moscow
A. D. Durnev
V. V. Zakusov Research Institute of Pharmacology
Email: zabrodinavv@gmail.com
Russian Federation, Moscow