Effect of Opiate Receptors Blockade on Microbicidal Potential and Production of IL-1β, TNFα, and IL-10 by Peritoneal Macrophages under Stress Conditions
- Authors: Gein S.V.1, Sharavieva I.L.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, the Ural Division of Russian Academy of Sciences
- Issue: Vol 161, No 3 (2016)
- Pages: 339-343
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237402
- DOI: https://doi.org/10.1007/s10517-016-3409-z
- ID: 237402
Cite item
Abstract
Rotation stress activated spontaneous and zymosan-induced ROS production. In animals receiving naloxone against the background of rotation stress, ROS production did not increase. Immobilization stress did not change the intensity of spontaneous and zymosan-induced ROS production, but inhibited stimulated ROS production against the background of naloxone treatment. Rotation produced a naloxone-independent inhibitory effect on spontaneous and stimulated IL-1β and TNFα production by macrophages and naloxone-dependent stimulating effect on spontaneous IL-10 production. Rotation stress did not modulate stimulated IL-10 production. In case of immobilization stress, decreased IL-1β and TNFα production was observed in mice exposed to stress under conditions of opiate receptors blockade; IL-10 production was not affected by immobilization stress. Both types of stress significantly increased plasma corticosterone levels, while naloxone had no effect on corticosterone production.
About the authors
S. V. Gein
Institute of Ecology and Genetics of Microorganisms, the Ural Division of Russian Academy of Sciences
Author for correspondence.
Email: gein@iegm.ru
Russian Federation, Perm
I. L. Sharavieva
Institute of Ecology and Genetics of Microorganisms, the Ural Division of Russian Academy of Sciences
Email: gein@iegm.ru
Russian Federation, Perm