Effects of Vascular Peptide Bioregulator on the Density of Microvascular Network in the Brain Cortex of Aged Rats
- Authors: Sokolova I.B.1, Ryzhak G.A.2, Mel’nikova N.N.1, Sergeev I.V.1, Khavinson V.K.2
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Affiliations:
- I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences
- St. Petersburg Institute of Bioregulation and Gerontology
- Issue: Vol 161, No 2 (2016)
- Pages: 300-303
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237353
- DOI: https://doi.org/10.1007/s10517-016-3400-8
- ID: 237353
Cite item
Abstract
Using a TV unit for microcirculation studies, we studied the density of the entire microvascular network and its arterial compartment in the pia mater of the sensorimotor cortex in intact young and aged rats (2-3 and 22-24 months) and aged rats after a course of vascular peptide bioregulator Slavinorm. The experiments showed that the density of microvascular network in intact animals decreased by 1.6 times with aging. Treatment with the peptide bioregulator 2.5-fold increased the density of the microvascular network in aged rats in comparison with intact animals of the same age, the density of the arterial compartment of the microvascular network in the pia mater increased by 2.8 times.
About the authors
I. B. Sokolova
I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences
Author for correspondence.
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg
G. A. Ryzhak
St. Petersburg Institute of Bioregulation and Gerontology
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg
N. N. Mel’nikova
I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg
I. V. Sergeev
I. P. Pavlov Institute of Physiology, the Russian Academy of Sciences
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg
V. Kh. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology
Email: sib@kolt.infran.ru
Russian Federation, St. Petersburg