Effects of N-[Imino(1-Piperidinyl)Methyl] Guanidine on the Intensity of Free Radical Processes, Aconitase Activity, and Citrate Level in the Tissues of Rats with Experimental Type 2 Diabetes Mellitus
- Authors: Skliarova E.I.1, Popova T.N.1, Shulgin K.K.1
-
Affiliations:
- Voronezh State University
- Issue: Vol 161, No 2 (2016)
- Pages: 261-265
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/237320
- DOI: https://doi.org/10.1007/s10517-016-3391-5
- ID: 237320
Cite item
Abstract
Effects of a synthetic biguanide derivative N-[imino(1-piperidinyl)methyl] guanidine (NIPMG) on free radical homeostasis, aconitase activity, and citrate concentration were studied in the liver and blood serum of rats with type 2 diabetes mellitus. Analysis of biochemiluminescence parameters showed that administration of this agent (10 mg/kg body weight) to animals with diabetes reduced the intensity of free radical processes in study tissues relative to the increased values in untreated diabetic animals. Under these conditions, aconitase activity, a principal target of ROS effects, and citrate level in the liver and blood serum of rats approached the control levels. The results show that NIPMG can positively regulate free radical homeostasis and reduce the intensity of oxidative stress in type 2 diabetes mellitus, which was accompanied by normalization of the studied parameters.
About the authors
E. I. Skliarova
Voronezh State University
Author for correspondence.
Email: katttilda@mail.ru
Russian Federation, Voronezh
T. N. Popova
Voronezh State University
Email: katttilda@mail.ru
Russian Federation, Voronezh
K. K. Shulgin
Voronezh State University
Email: katttilda@mail.ru
Russian Federation, Voronezh