Peculiarities of the Inflammatory Process in the Reproductive Organs of C57Bl/6 Female Mice with Experimental Tuberculosis
- Authors: Sukhikh G.T.1, Kayukova S.I.2, Bocharova I.V.2, Donnikov A.E.1, Lepekha L.N.2, Demikhova O.V.2, Uvarova E.V.1, Berezovskii Y.S.2, Smirnova T.G.2
-
Affiliations:
- V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Research Central Institute of Tuberculosis
- Issue: Vol 160, No 6 (2016)
- Pages: 787-790
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236945
- DOI: https://doi.org/10.1007/s10517-016-3310-9
- ID: 236945
Cite item
Abstract
Intravenous infection of C57Bl/6 female mice with M. tuberculosis H37Rv led to involvement of the lungs and dissemination of the tuberculous infection to the abdominal and pelvic organs. M. tuberculosis were detected in the lungs and spleen in 14, 35, and 90 days and in the uterine horns in 90 days after infection. Morphological analysis of organs showed successive development of exudative necrotic tuberculosis of the lungs, acute and chronic nonspecific inflammation in the reproductive organs (vagina, uterus, and uterine horns). The inflammatory process in the reproductive organs was associated with the development of anaerobic dysbiosis, that was most pronounced in 35 days after infection. Antituberculous therapy was followed by reduction of M. tuberculosis count in the lungs and spleen in 60 and 90 days after infection, eliminatation of M. tuberculosis in the uterine horns, arrest of nonspecific inflammation in female reproductive organs, recovery of the balance between aerobic and anaerobic microflora, and development of candidiasis of the urogenital mucosa.
About the authors
G. T. Sukhikh
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
S. I. Kayukova
Research Central Institute of Tuberculosis
Author for correspondence.
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
I. V. Bocharova
Research Central Institute of Tuberculosis
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
A. E. Donnikov
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
L. N. Lepekha
Research Central Institute of Tuberculosis
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
O. V. Demikhova
Research Central Institute of Tuberculosis
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
E. V. Uvarova
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
Yu. S. Berezovskii
Research Central Institute of Tuberculosis
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
T. G. Smirnova
Research Central Institute of Tuberculosis
Email: kajukovalnp@gmail.com
Russian Federation, Moscow
![](/img/style/loading.gif)