Efficiency of Cell Therapy in Liver Cirrhosis
- Authors: Shevela E.Y.1, Starostina N.M.1, Pal’tsev A.I.1, Shipunov M.V.1, Zheltova O.I.1, Meledina I.V.1, Khvan L.A.1, Leplina O.Y.1, Ostanin A.A.1, Chernykh E.R.1, Kozlov V.A.1
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Affiliations:
- Research Institute of Clinical Immunology
- Issue: Vol 160, No 4 (2016)
- Pages: 542-547
- Section: Article
- URL: https://journals.rcsi.science/0007-4888/article/view/236778
- DOI: https://doi.org/10.1007/s10517-016-3215-7
- ID: 236778
Cite item
Abstract
We studied safety and clinical efficacy of transplantation of autologous bone marrow cell in complex therapy of 158 patients with chronic hepatitis and cirrhosis of the liver. The efficiency of cell therapy was assessed in 12 months after single injection of the cells. The positive response (alleviation of liver cirrhosis or stabilization of the pathological process) was observed in 70% cases. The efficacy of therapy correlated with the severity and etiology of the disease and was maximum in patients with Child–Pugh class A (in 82.5% cases) and class B liver cirrhosis (in 79% cases); in patients with class C liver cirrhosis, the positive response was achieved in 42.5% cases. In 39 patients, ultrasonic examination performed in 3 years after transplantation revealed no focal lesions or ectopic ossification foci.
About the authors
E. Ya. Shevela
Research Institute of Clinical Immunology
Author for correspondence.
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
N. M. Starostina
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
A. I. Pal’tsev
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
M. V. Shipunov
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
O. I. Zheltova
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
I. V. Meledina
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
L. A. Khvan
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
O. Yu. Leplina
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
A. A. Ostanin
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
E. R. Chernykh
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk
V. A. Kozlov
Research Institute of Clinical Immunology
Email: ct_lab@mail.ru
Russian Federation, Novosibirsk