Email this article The effect of molixan, a disulfide-containing immunomodulator, on Na+ transport across frog skin epithelium
- Authors: Melnitskaya A.V1, Krutetskaya Z.I1, Antonov V.G2, Krutetskaya N.I1
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Affiliations:
- Saint Petersburg State University
- Saint Petersburg State Pediatric Medical University
- Issue: Vol 68, No 5 (2023)
- Pages: 949-953
- Section: Articles
- URL: https://journals.rcsi.science/0006-3029/article/view/233466
- DOI: https://doi.org/10.31857/S0006302923050150
- EDN: https://elibrary.ru/PHJODD
- ID: 233466
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Abstract
The effect of molixan, a disulfide-containing immunomodulator which is an analogue of oxidized glutathione, on Na+ transport across frog skin epithelium has been studied. Using the voltage-clamp technique, the capacity of molixan to modulate Na+ transport across frog skin epithelium has been revealed for the first time. It was also found that when molixan is applied to the apical surface of frog skin, it suppresses Na+ transport, while molixan added on the basolateral surface may mimic the effect of insulin and stimulate Na+ transport. The results obtained indicate that oxidized glutathione and its analogs molixan and glutoxim unidirectionally modulate Na+ transport across frog skin.
Keywords
About the authors
A. V Melnitskaya
Saint Petersburg State University
Email: a.melnitskaya@spbu.ru
Saint Petersburg, Russia
Z. I Krutetskaya
Saint Petersburg State UniversitySaint Petersburg, Russia
V. G Antonov
Saint Petersburg State Pediatric Medical UniversitySaint Petersburg, Russia
N. I Krutetskaya
Saint Petersburg State UniversitySaint Petersburg, Russia
References
- Ю. В. Наточин, Основы физиологии почки (Наука, Л., 1982).
- D. J. Benos and B. A. Stanton, J. Physiol., 520, 631 (1999).
- D. Firsov, M. Robert-Nicoud, S. Gruender, et al., J. Biol. Chem., 274, 2743 (1999).
- S. Kellenberger, I. Gautschi, Y. Pfister, et al., J. Biol. Chem., 280, 7739 (2005).
- V. Koefoed-Johnsen and H. H. Ussing, Acta. Physiol. Scand., 42, 298 (1958).
- A. A. Boldyrev and E. R. Bulygina, Ann. N.Y. Acad. Sci., 834, 666 (1997).
- J. D. Hayes and L. I. McLellan, Free Rad. Res., 31, 273 (1999).
- В. И. Кулинский и Л. С. Колесниченко, Биомед. химия, 55 (4), 365 (2009).
- J. D. Uys, P. J. Mulholland, and D. M. Townsend, Biomed. Pharmacother., 68, 799 (2014).
- A. E. Borisov, L. A. Kozhemyakin, A. E. Antushevich, et al., Vestn. Hirurgii im. I. I. Grekova, 4 (2), 32 (2001).
- О. Б. Жуков, А. Р. Зубарев, М. В. Мезенцева и др., Врачебное сословие, 5 (6), 51 (2004).
- Z. I. Krutetskaya, O. E. Lebedev, A. V. Melnitskaya, et al., Dokl. RAN, 421 (5), 709 (2008).
- C. A. Downs, L. Kreiner, X. M. Zhao, et al., Am. J. Physiol., 308, L943 (2015).
- Е. Б. Бурова, К. П. Василенко, В. Г. Антонов и др., Докл. РАН, 404, 1 (2005).
- К. П. Василенко, Е. Б. Бурова, В. Г. Антонов и др., Цитология, 48 (6), 500 (2006).
