Localization of Galectins within Glycocalyx
- 作者: Rapoport E.1, Matveeva V.1, Vokhmyanina O.1, Belyanchikov I.1, Gabius H.2, Bovin N.1
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隶属关系:
- Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry
- Faculty of Veterinary Medicine, Institute of Physiological Chemistry
- 期: 卷 83, 编号 6 (2018)
- 页面: 727-737
- 栏目: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151675
- DOI: https://doi.org/10.1134/S000629791806010X
- ID: 151675
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详细
Galectins are involved in various biological processes, e.g. cell–cell and cell–matrix adhesion and the transmission of cellular signals. Despite the diversity of functions, little is known about the nature of their physiological cognate ligands on the cell surface and the localization of galectins in the glycocalyx, although this information is important for understanding the functional activity of galectins. In this work, localization of endogenous and exogenously loaded galectins in the glycocalyx was studied. The following main conclusions are drawn: 1) galectins are not evenly distributed within the glycocalyx, they are accumulated in patches. Patching is not the result of a cross-linking of cellular glycans by galectins. Instead, patch-wise localization is the consequence of irregular distribution of glycans forming the glycocalyx; 2) galectins are accumulated in the inner zone of the glycocalyx rather than at its outer face or directly in vicinity of the cell membrane; 3) patches are not associated with cell rafts.
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作者简介
E. Rapoport
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry
Email: professorbovin@yandex.ru
俄罗斯联邦, Moscow, 117997
V. Matveeva
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry
Email: professorbovin@yandex.ru
俄罗斯联邦, Moscow, 117997
O. Vokhmyanina
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry
Email: professorbovin@yandex.ru
俄罗斯联邦, Moscow, 117997
I. Belyanchikov
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry
Email: professorbovin@yandex.ru
俄罗斯联邦, Moscow, 117997
H.-J. Gabius
Faculty of Veterinary Medicine, Institute of Physiological Chemistry
Email: professorbovin@yandex.ru
德国, Veterinärstr. 13, Munich, D-80539
N. Bovin
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry
编辑信件的主要联系方式.
Email: professorbovin@yandex.ru
俄罗斯联邦, Moscow, 117997
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