2,5-Diketopiperazines: A New Class of Poly(ADP-ribose)polymerase Inhibitors
- 作者: Nilov D.1, Yashina K.2, Gushchina I.2, Zakharenko A.3, Sukhanova M.3, Lavrik O.3, Švedas V.1,2
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隶属关系:
- Belozersky Institute of Physico-Chemical Biology
- Faculty of Bioengineering and Bioinformatics
- Institute of Chemical Biology and Fundamental Medicine
- 期: 卷 83, 编号 2 (2018)
- 页面: 152-158
- 栏目: Article
- URL: https://journals.rcsi.science/0006-2979/article/view/151601
- DOI: https://doi.org/10.1134/S0006297918020074
- ID: 151601
如何引用文章
详细
We show for the first time that natural 2,5-diketopiperazines (cyclic dipeptides) can suppress the activity of the important anticancer target poly(ADP-ribose)polymerase (PARP). Cyclo(L-Ala-L-Ala) and cyclo(L-Ala-D-Ala) can interact with the key residues of the PARP-1 active site, as demonstrated using docking and molecular dynamics simulations. One of the amide groups of cyclo(L-Ala-L-Ala) and cyclo(L-Ala-D-Ala) forms hydrogen bonds with the Gly863 residue, while the second amide group can form a hydrogen bond with the catalytic residue Glu988, and the side chain can make a hydrophobic contact with Ala898. Newly identified diketopiperazine inhibitors are promising basic structures for the design of more effective inhibitors of PARP family enzymes. The piperazine core with two chiral centers provides many opportunities for structural optimization.
作者简介
D. Nilov
Belozersky Institute of Physico-Chemical Biology
Email: vytas@belozersky.msu.ru
俄罗斯联邦, Moscow, 119991
K. Yashina
Faculty of Bioengineering and Bioinformatics
Email: vytas@belozersky.msu.ru
俄罗斯联邦, Moscow, 119991
I. Gushchina
Faculty of Bioengineering and Bioinformatics
Email: vytas@belozersky.msu.ru
俄罗斯联邦, Moscow, 119991
A. Zakharenko
Institute of Chemical Biology and Fundamental Medicine
Email: vytas@belozersky.msu.ru
俄罗斯联邦, Novosibirsk, 630090
M. Sukhanova
Institute of Chemical Biology and Fundamental Medicine
Email: vytas@belozersky.msu.ru
俄罗斯联邦, Novosibirsk, 630090
O. Lavrik
Institute of Chemical Biology and Fundamental Medicine
Email: vytas@belozersky.msu.ru
俄罗斯联邦, Novosibirsk, 630090
V. Švedas
Belozersky Institute of Physico-Chemical Biology; Faculty of Bioengineering and Bioinformatics
编辑信件的主要联系方式.
Email: vytas@belozersky.msu.ru
俄罗斯联邦, Moscow, 119991; Moscow, 119991